Psoriatic arthritis medications: A comprehensive guide

From krdo.com

Psoriatic arthritis is an autoimmune condition that causes joint inflammation, skin symptoms, and pain. People searching for psoriatic arthritis prescriptions are often looking for detailed information about medication options, their effectiveness, potential side effects, and ways to manage costs.

This guide from SaveHealth, a prescription discount/savings card website, explores the most commonly prescribed medications for psoriatic arthritis, including DMARDs, biologics, and NSAIDs, while highlighting considerations for effectiveness, safety, and cost.

                                                                                              Ray Geiger // Shutterstock

How Psoriatic Arthritis Medications Work

Medications for psoriatic arthritis aim to reduce inflammation, slow disease progression, and relieve pain. They work through different mechanisms depending on the drug class.

Major medication categories:

• DMARDs (Disease-Modifying Anti-Rheumatic Drugs): These slow disease progression and prevent joint damage. Examples include methotrexate and leflunomide.
• Biologics: Target specific components of the immune system to control inflammation. Examples include Skyrizi and Humira.
• NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): Provide temporary relief from pain and stiffness without altering disease progression. Examples include naproxen and celecoxib.
• Corticosteroids: Offer rapid symptom relief during flare-ups but are generally used short term.
• PDE-4 Inhibitors: Commonly known as phosphodiesterase-4 inhibitors, these drugs work by blocking the PDE-4 enzyme which ultimately helps to lower inflammation in the body. A frequent used example is Otezla.

Top Psoriatic Arthritis Medications

The following medications are among the most commonly prescribed for psoriatic arthritis. They include both traditional and newer therapies.

DMARDs

• Methotrexate: Often first-line therapy for psoriatic arthritis. It slows joint damage and inflammation.
• Leflunomide: Useful for patients who cannot tolerate methotrexate.
• Sulfasalazine: Reduces joint inflammation and can improve skin symptoms.

Biologics

• Skyrizi (risankizumab): Targets interleukin-23, reducing inflammation and improving both joint and skin symptoms.
• Humira (adalimumab): TNF inhibitor that helps reduce pain and swelling.
• Enbrel (etanercept):TNF inhibitor that can slow joint damage and improve quality of life.
• Stelera, Imuldosa, Otulfi, Pyzchiva, Selarsdi, Steqeyma (ustekinumab): Targets IL-12 and IL-23 to control inflammation.

NSAIDs

• Naproxen: Reduces pain and stiffness.
• Celecoxib: Offers pain relief with reduced gastrointestinal risk compared to traditional NSAIDs.

Corticosteroids

• Prednisone: Provides rapid relief during flares but is not intended for long-term use due to side effects.

Psoriatic Arthritis Medication Comparison

SaveHealth

Otezla PDE-4 inhibitor Oral Significant joint relief Nausea, decreased in 16 weeks appetite, weight loss, anxiety, insomnia.

Common Side Effects of Psoriatic Arthritis Medications

Side effects vary depending on the type of medication and individual response.

DMARDs

• Nausea
• Fatigue
• Liver enzyme elevation

Biologics

• Increased risk of infections
• Injection site reactions
• Upper respiratory infections

NSAIDs

• Stomach upset
• Kidney issues
• Increased bleeding risk

Corticosteroids

• Bone loss
• Weight gain
• Mood changes

PDE-4 inhibitors

• Gi side effects (Nausea, diarrhea, decreased appetite, abdominal pain, weight loss)
• Headache, dizziness, insomnia, anxiety, nervousness
• Infections (upper respiratory infections)

Choosing A Psoriatic Arthritis Medication

Selecting the appropriate psoriatic arthritis medication requires balancing effectiveness, side effect tolerance, convenience, and cost.

Factors to consider:

• Severity of joint and skin symptoms
• Past medication response
• Risk of side effects
• Administration preference (oral vs injection)
• Insurance coverage and out-of-pocket cost

Tips for Managing Psoriatic Arthritis Medication Costs

Psoriatic arthritis medications, particularly biologics and DMARDs, can be costly. Patients can reduce expenses by:

• Comparing pharmacy prices
• Considering generic options for DMARDs
• Exploring manufacturer savings programs
• Reviewing insurance co-pay assistance
• Planning prescriptions to avoid gaps in therapy

Even small monthly savings can make a significant difference for long-term disease management.

Psoriatic Arthritis Medications & Prescriptions

Psoriatic arthritis management involves a range of medications, including DMARDs, biologics, NSAIDs, and corticosteroids. Understanding options like Methotrexate, Leflunomide, Sulfasalazine, Skyrizi, Humira, Enbrel, Stelara, Naproxen, Celecoxib, and Prednisone helps patients select effective therapies for their condition. Working closely with a healthcare provider while considering effectiveness, safety, and affordability can optimize long-term outcomes.

https://krdo.com/stacker-science/2025/12/31/psoriatic-arthritis-medications-a-comprehensive-guide/#google_vignette 

Rheumatoid Arthritis Grocery List: Best Food Choices From Each Aisle

From everydayhealth.com

Rheumatoid arthritis (RA) is an autoimmune disease that causes swelling, stiffness, and inflammation in the joints as the immune system attacks its own body’s tissues. And while diet alone can’t treat it, rheumatologists and registered dietitians often advise people to eat more anti-inflammatory foods to ease symptoms. 

Research suggests that the Mediterranean diet, made up of foods rich in antioxidants, fibre, and heart-healthy fats, helps to reduce inflammation and increase physical function, making it part of managing rheumatoid arthritis and its symptoms.

“It is absolutely essential to work with nutrition to manage rheumatoid arthritis well,” says Caylee Clay, RDN, a Brooklyn, New York–based registered dietitian-nutritionist specializing in autoimmune diseases, including RA and psoriasis.

As always, you should speak with your healthcare provider before making major changes to your diet. 

                                                                                                                  Everyday Health

Produce Aisle

If there’s one part of the grocery store where you truly can’t go wrong, it’s the produce section, according to Ginger Hultin, DSc, a registered dietitian-nutritionist in Seattle and a nutrition expert source for the Arthritis Foundation. 

Fruits and vegetables provide antioxidants, vitamins, minerals, and fibre — all of which support immune function and help to combat inflammation, she says. In general, darker-colored produce contains higher levels of protective plant compounds.

Hultin suggests:

• Leafy greens (spinach, lettuce, and arugula)
• Cruciferous vegetables (broccoli, cauliflower, cabbage, kale, and Brussels sprouts)
• Red and orange vegetables (carrots, bell peppers, and squash)
• White vegetables (garlic, onions, scallions, and shallots)
• Root vegetables (potatoes, sweet potatoes, parsnips, and turnips)
• Citrus fruits (oranges, tangerines, lemons, and limes)
• Berries (strawberries, blueberries and blackberries, fresh or frozen)

When you’re filling your shopping cart in this aisle, try to “eat the rainbow,” recommends Clay. And don’t forget herbs and spices, which are some of the richest sources of antioxidants, Clay says.

Meat Department

Protein sources in the Mediterranean diet focus on fatty fish and poultry, both anti-inflammatory options for people with rheumatoid arthritis. The diet also limits red and processed meats.

Hultin recommends:

• Fish, such as salmon, halibut, mackerel, herring, anchovies and sardines, which are packed with omega-3 fatty acids
• Leaner meat options, including skinless chicken and turkey
• Meat alternatives like tofu and tempeh

When choosing protein sources while living with RA, limit red meat to two to three servings per week, Clay says. This includes beef, pork, and lamb. “These meats tend to be higher in saturated fats, which can drive heart disease,” Clay says.

Dairy Aisle

Dairy’s role in an anti-inflammatory diet for people with rheumatoid arthritis is complicated. Research shows that while dairy products have been shown to be weakly anti-inflammatory, dairy consumption may also increase RA risk and more studies need to be done. As part of the Mediterranean diet, for example, dairy is meant to be consumed in moderation.

Calcium intake is important for people with RA who are at a higher risk of osteoporosis because of steroid use, says Scott Zashin, MD, a rheumatologist in Dallas and a co-author of several books about arthritis management, including Natural Arthritis Treatment. But calcium doesn’t necessarily need to come from dairy products.

“We want to try to focus on foods that have a higher intake of calcium as opposed to depending on calcium supplements. That’s dairy, but it also includes leafy green vegetables,” Dr. Zashin says.

Some people may find their RA symptoms worsen with higher-fat or heavily processed dairy options, Clay says. That’s why you should look for no added sugar and a decent protein content in your dairy sources.

Clay suggests looking for:

• Unsweetened yogurts, such as plain yogurt, Greek yogurt, or kefir — a fermented yogurt with probiotics (you can add flavors, such as cinnamon and fruit in your own home, according to Clay)
• Low-fat milk for protein and calcium without excess saturated fat
• Dairy milk alternatives, such as almond, cashew, and soy milk

Fermented dairy, which contains probiotics, benefits people with RA through cultivating a healthy microbiome, Zashin says. Foods like yogurt and kefir introduce healthy bacteria that work to reduce inflammation, support immune function, and improve overall gut health, which may in turn lessen RA flare-ups, he explains.

Shelf-Stable Foods

The interior aisles of the grocery store are packed with long-lasting essentials that can make meal planning for RA more convenient — and budget-friendly, says Hultin.

She suggests:

• Dried and canned beans and legumes
• Nuts, seeds, nut and seed butters, and trail mix
• Canned fish like salmon, tuna, and sardines
• Whole grains like whole-wheat pasta and brown rice
• Olive oil

Remember to buy what you like and will make use of, too, Clay says. “Enjoying our food is always a key ingredient, so must-have shelf-stable foods will vary from person to person, based on their tastes and preferences.”

Frozen Foods

Frozen options can be just as nutritious as fresh — and they’re often more affordable, Hultin says.

You can stock up on Mediterranean diet staples, such as:

• Frozen fish and shellfish
• Frozen vegetables
• Frozen fruits

“These foods can be more affordable, last longer in your freezer, and save [you] from the task of chopping and prepping if [you’re] having trouble with mobility,” Hultin says. They’re also versatile — you can add frozen ingredients to smoothies, soups, stir-fries, and plenty of other dishes.

Beverages

People living with RA should pay attention to what they’re drinking, in case they’re racking up the calories, added sugar, and fat via coffee creamers, soda, and juice, Hultin says.

Hydration supports overall health, digestion, and joint function — and water is almost always the best choice. 

Other beverages can fit into an RA-friendly plan, Hultin says. They include:

• Tea, especially green or herbal teas rich in antioxidants
• Coffee, without creamers, honey, or added sugar
• Sparkling water

Try to cut back on alcohol because of potential interactions with medications that treat RA, Zashin says, pointing to methotrexate — a first-line drug for RA patients — as a prime example.

Snack Aisle

While the Mediterranean diet emphasizes lean proteins, fresh produce, and healthy fats, it limits added sugars, sodium, highly processed foods, and saturated fats, the American College of Rheumatology notes in its treatment guidelines for RA.

Based on these guidelines, Hultin says RA-friendly snacks should emphasize fibre, healthy fats, and protein over refined carbohydrates and sugar. This includes:

• Popcorn (air-popped is best)
• Whole-grain chips or crackers
• Dark chocolate
• Unsweetened dried fruit

The Takeaway

• Research shows that foods rich in antioxidants, fibre, and heart-healthy fats, can reduce inflammation, which can help you manage rheumatoid arthritis symptoms. 
• Antioxidants, vitamins, minerals, and fibre in fruits and vegetables support immune function and help fight inflammation. Also look for sources of lean protein and low-fat dairy products. And nuts, seeds, legumes, and whole grains should be on your shopping list, too.
• Avoid highly processed foods, which tend to contain added sugars and saturated fats that can worsen inflammation. 
• Talk to your doctor and consider consulting a nutritionist to make the best dietary choices for you. 

https://www.everydayhealth.com/rheumatic-conditions/rheumatoid-arthritis-grocery-list/