From futura-sciences.com
Nearly one in four adults over 40 lives with the daily discomfort of osteoarthritis, a condition that gradually wears down the cartilage cushioning the joints. Once that cartilage is damaged, there is no way to restore it. For many patients, treatment becomes a long road of pain medication, eventually leading to joint replacement surgery
A study published in The Lancet Rheumatology on August 12, 2025 suggests there may be another option: gait retraining. Researchers from the University of Utah, New York University, and Stanford University found that adjusting the angle of the foot while walking can significantly reduce pain. Also slowing cartilage deterioration in the knee. The findings come from a year long randomized controlled trial.
What if changing the way you walk could really relieve arthritis? © HarbucksFirst placebo controlled proof
Co-led by Scott Uhlrich, assistant professor of mechanical engineering in Utah’s John and Marcia Price College of Engineering, the study is the first placebo controlled trial to show that a biomechanical intervention can effectively treat osteoarthritis symptoms. “We’ve known that for people with osteoarthritis, higher loads in their knee accelerate progression, and that changing the foot angle can reduce knee load,” Uhlrich said. “So the idea of a biomechanical intervention is not new, but there have not been randomized, placebo-controlled studies to show that they’re effective.”
Participants who modified their walking pattern reported pain relief comparable to common medications. Furthermore, MRI scans revealed slower cartilage deterioration in those who adopted the personalized walking adjustments, compared to those who received a sham treatment. “The reported decrease in pain over the placebo group was somewhere between what you’d expect from an over-the-counter medication, like ibuprofen, and a narcotic, like OxyContin,” Uhlrich said.
A personalised approach to knee osteoarthritis
The researchers focused on individuals with mild to moderate knee osteoarthritis affecting the medial compartment. Specifically the knee’s inner side, which bears more load than the outer. Earlier studies often prescribed the same foot angle change to everyone. Not every knee responds the same way. For some participants, a standard adjustment did little to reduce joint loading and could even worsen it. This time, the team opted for a personalized strategy.
Lead researcher Scott Uhlrich measures a participant’s gait. At the beginning of the study, participants received a baseline MRI and walked on a force-sensitive treadmill while motion-capture cameras recorded their walking mechanics. © Utah Movement Bioengineering LabUsing motion capture cameras and a pressure sensitive treadmill, researchers measured how each participant’s knee responded when they walked with their toes pointed slightly inward or outward. They then determined whether a five or ten degree shift reduced stress most effectively. Participants for whom no foot angle change reduced knee stress were excluded. That careful selection required screening 1,582 volunteers to recruit 68 participants, and may explain why previous trials produced inconclusive results.
Placebo versus intervention
After baseline MRI scans and gait assessments, the 68 participants divided into two groups. One group received a sham intervention, walking with a foot angle identical to their natural gait. The other adopted a customized foot angle shown to reduce knee loading. Both groups attended six weekly training sessions, during which a device attached to the shin delivered gentle vibrations as biofeedback, helping participants maintain their prescribed foot position while walking on a treadmill.
After the supervised phase, participants practiced their new gait for at least 20 minutes daily. Follow-up visits confirmed remarkable precision, with most staying within one degree of their assigned angle. After a year, participants reported their pain levels and underwent a second MRI. The reduction in pain fell somewhere between an over-the-counter anti-inflammatory and a stronger prescription painkiller. Meanwhile, imaging showed measurable protection of cartilage health.
A long term option for pain management
Beyond the numbers, participants expressed enthusiasm for the approach. One told researchers:
“I don’t have to take a drug or wear a device — it’s just a part of my body now that will be with me for the rest of my days, so that I’m thrilled with.” For many, the appeal was its simplicity. No daily medication. No device to wear indefinitely.
The motion capture technology used in the study is expensive and time consuming. However, researchers are developing mobile solutions using smartphone video and smart footwear to make personalization feasible in physical therapy clinics. “Especially for people in their 30s, 40s, or 50s, osteoarthritis could mean decades of pain management before they’re recommended for a joint replacement,” Uhlrich said. “This intervention could help fill that large treatment gap.” Further studies are needed before the approach can be rolled out broadly, but the trial’s scale and design give the findings more credibility than most early stage interventions can claim.






